Ahead of Friday’s opening World Cup match against New Zealand, hosts France have selected Yoram Moefana to play inside center.
Moefana, 23, will wear the number 12 shirt in the absence of the injured Jonathan Danty.
Prop Cyril Baille is ruled out of the opener in Paris through injury.
“We’re getting into this match with the best France team,” head coach Fabien Galthie said on Wednesday.
Moefana, who has 18 caps, will partner the experienced Gael Fickou in midfield, while Dupont will captain the side.
Lock Bastien Chalureau is not included in the matchday 23.
On Monday the 31-year-old denied accusations he is a racist after being called up to the France squad as injury cover.
Chalureau is appealing against a six-month prison sentence for a racially motivated attack in 2020.
France are targeting a first World Cup title after finishing their preparations with a comfortable 41-17 win over Australia.
France team to face New Zealand: Ramos; Penaud, Fickou, Moefana, Villiere; Jalibert, Dupont (capt); Wardi, Marchand, Atonio, Woki, Flament, Cros, Ollivon, Alldritt.
Replacements: Mauvaka, Gros, Aldegheri, Taofifenua, Boudehent, Lucu, Vincent, Jaminet.