Sino Biopharm Announces 2019 Annual Results

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Revenue Climbs 16.% to RMB24.23 billion Underlying Profit Up 10.2% to RMB3.13 billion

Achieves an outstanding R&D performance and obtains 28 production
approvals

 

Financial Highlights

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 For the Year Ended 31 December

 

RMB

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2019

2018

Change

Revenue (million)

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24,234

20,889

+16.0%

Underlying Profit*
(million)

3,132

2,841

+10.2%

Profit Attributable
to Owners of the Parent (million)

2,707

9,046

-70.1%

Basic Earnings** per
Share (cents)

24.97

22.98

+8.7%

Total Dividend per
Share (HK cents)

8.00

8.0

 

–      
First Quarter

2.0

2.0

 

–      
Second Quarter

2.0

2.0

 

–      
Third Quarter

2.0

2.0

 

–      
Fourth Quarter

2.0

2.0

 

* Refers to profit attributable to the
owners of the parent excluding the impact of (i) one-off gain on step acquisition
and annual amortization expenses of new identifiable intangible assets arising
from the acquisition of 24% interests in Beijing Tide; and (ii) unrealized fair
value losses(net) on equity investments and financial assets

** Based on underlying profit 


Results Highlights

  • A total of 28 products including Lenalidomide capsules, Abiraterone
    Acetate tablet and several indications of Anlotinib capsules obtained the
    approval for drug registration granted by the National Medical Products
    Administration. Over 40% of these products are oncology drugs and the
    competitive edge of our oncology product line has been substantially enhanced.
    Some 19 products have passed (or are deemed to have passed) the Consistency
    Evaluation.
  • Commanding a total investment of RMB3 billion and occupying an area of
    520 mu, CT Tianqing’s new drug R&D and production base opened,
    significantly boosting the Group’s integrated strength in the biopharmaceutical
    area.
  • Sino Biopharm ranked 42nd in U.S. magazine Pharm Exec‘s “Top 50 Companies 2019”, as one of the only two
    Chinese companies on the list.
  • Sino Biopharm garnered several awards at “The All-Asia-Executive Team
    2019” held by Institutional Investor,
    and ranked 3rd among the “Honored Companies”.
  • Sino Biopharm was the only Chinese pharmaceutical company named among Forbes
    “Asia 200 Best Over a Billion 2019”.
  • The quality control study “Shortening the Lyophilization Cycle of
    Product ‘F'” presented by CT Tianqing, a subsidiary of the Company, won the
    International Quality Gold Award at the 44th International Convention on
    Quality Control Circles (ICQCC) held in Tokyo, Japan.
  • At the “China ChemPharm Annual Summit 2019”, Sino Biopharm’s
    subsidiaries, namely CT Tianqing, Beijing Tide, NJCTT, Jiangsu CT Fenghai and
    CP Qingdao, were included in the Top 100 List of “Outstanding Enterprises and
    Outstanding Product Brands in China’s Chemical Pharmaceutical Industry 2019”.
    CT Tianqing again led the “Ranking of Top 100 R&D Capabilities of Chinese
    Chemicals Enterprises in 2019” and ranked 2nd in the “2019 Top 100 Enterprises
    in the PRC Pharmaceutical Industry — Comprehensive R&D Strength”.
  • CT Tianqing ranked 16th and Beijing Tide ranked 41st in the list of the
    “2018 Top 100 Pharmaceutical Companies in China” released at the “2019 (36th
    session) National Pharmaceutical Industry Annual Information Conference”.
  • Sino Biopharm ranked 1st among the “Top 20 Most Competitive Listed
    Chinese Pharmaceutical Companies” released at the “2019 China Healthcare Summit
    of Entrepreneurs, Scientists and Investors”, and at the same time also ranked
    2nd in the first-tier category of “Top 100 Innovative Pharmaceutical
    Enterprises in China”.
  • Eight new drug studies conducted by CT Tianqing were recognised as
    “National Major Innovative Drug Projects”. The number of drug studies approved
    was among the highest in the country.
  • Chia Tai Tianqing Akeso (Shanghai) Biomedical Technology Company
    Limited, a joint-venture company invested jointly by CT Tianqing and Akeso
    Biopharma, was officially set up in Shanghai. The joint venture is engaged in
    the development of the differentiated tumor immunotherapy PD-1 antibody drugs.

 

HONG KONG, CHINA
– Media OutReach – March
30, 2020 – Sino Biopharmaceutical Limited (“Sino Biopharm” or the “Company”, together
with its subsidiaries, the “Group”) (HKEX: 1177), a leading, innovative
research and development driven pharmaceutical conglomerate in the PRC, has
announced its financial results for the year ended 31 December 2019 (“the year”).
The Group’s overall results for the year continued to show considerable growth.
The share of revenue contributed by new products in the Group’s total revenue
also increased notably, demonstrating its mature integrated capability in
launching and promoting innovative products.

 

Results

During the year, the Group recorded revenue
of approximately RMB24.23 billion, representing an increase of approximately 16.0%
over the last year. Profit attributable to the owners of the parent was
approximately RMB2.71 billion, approximately 70.1% lower than that of the last
year. Such year-on year decrease was only due to the absence of a substantial
one-off gain on step acquisition recorded last year. Excluding the impact of the
one-off gain on step acquisition and the annual amortization expenses of new
identifiable intangible assets arising from the acquisition of 24% interests in
Beijing Tide, as well as the unrealized net fair value losses on equity
investments and financials assets, underlying profit attributable to owners of
the parent amounted to approximately RMB3.13 billion, increased by
approximately 10.2% as compared with the last year. Based on underlying profit
attributable to the owners of the parent, the earnings per share were approximately
RMB24.97 cents, 8.7% higher than the last year. The Group has maintained a
strong financial position with cash and bank balances reaching approximately
RMB11.91 billion at the year end.

 

The Board of Directors recommended a final
dividend payment of HK2.0 cents per share. Together with the dividend of HK2.0
cents already paid in each of the first three quarters, the total dividends for
the year amounted to HK8.0 cents (2018: HK8.0 cents).

Business Highlights

During the year, the Group has re-located
more resources in strengthening R&D and focused its academic promotion on
oncology drugs and other new products with less competition. Two new
indications of Anlotinib capsules have been approved and subsequently achieved
great sales success. Other oncology drugs including Yinishu, Yigu, Shoufu,
Qianping, Saiweijian and a recently approved product, Yijiu, analgesic
medicines including Flurbiprofen cataplasm, cardio-cerebral medicines including
Kaina and Xijia, digestive system medicines including Aisuping, Getai and Deyou
and anti-infectious medicines including Tianjie and Tianli all enjoyed rapid
growth. Markets for infusion solution products including Fenghaina, Qingkeping
and the newly-launched contrast agent product Qingliming also expanded, leading
to fast growth in sales.

 

During the year, the Group achieved an
outstanding research and
development (“R&D”)
performance and the Group obtained 28 production approvals and had 19 products
passed Consistency Evaluation. Also, 23 products obtained clinical approval.
The Group has made 25 new production applications and filed 19 new clinical
trial applications. In addition, some 26 new applications for Consistency
Evaluation have been accepted. The Group has obtained 83 invention patent
approvals and filed 341 applications for invention patents. In addition, Tenofovir Disoproxil Fumarate
tablet (Qingzhong) has obtained Marketing Authorization (MA) from the EU,
marking a milestone for the Group to officially enter into the international
mainstream market.

 

During the year, the sales
performance of the Group’s major medicine categories are outlined below:

 

Hepatitis medicines

–    The sales of hepatitis medicines amounted to
approximately RMB5,739.72 million, representing approximately 23.7% of the Group’s revenue.

  • Tianqingganping enteric capsules sales
    amounted to approximately RMB525.04 million, an increase of approximately 22.5%
    against the last year.
  • Tianqingganmei injections recorded sales
    of approximately RMB1,803.57 million, an increase of approximately 5.5% against
    the last year.

 

Oncology medicines

–    The sales of oncology medicines amounted to
approximately RMB5,427.88 million, representing approximately 22.4% of the Group’s revenue.

  • Sales of Saiweijian injections amounted to
    approximately RMB704.52 million during the review period, an increase of
    approximately 37.5% as compared with the last year.
  • Sales of Yinishu tablets amounted to approximately RMB224.90
    million, a significant increase of approximately 36.8% as compared with the
    last year.
  • Sales of Shoufu tablets amounted to
    approximately RMB214.16 million, an increase of 26.6% as compared with the last
    year.
  • Sales of new product Anxian capsules
    amounted to approximately RMB176.06 million.
  • Sales of another new product Qianping
    injections amounted to approximately RMB166.75 million, a sharp increase of
    125.7% as compared with the last year.

 

Cardio-cerebral medicines

–    The sales of cardio-cerebral medicines
amounted to approximately RMB3,116.29 million, representing approximately 12.9% of the Group’s revenue.

  • Sales of Yilunping tablets amounted to
    approximately RMB910.34 million, a year-on-year increase of approximately 16.2%.
  • Sales of Tuotuo calcium tablets amounted
    to approximately RMB753.55 million, a year-on-year increase of approximately 14.8%.
  • Sales of Kaina tablets amounted to
    approximately RMB513.07 million, an increase of approximately 25.1% as compared
    with the last year.

 

Orthopedic medicines

–    The sales of orthopedic medicines amounted
to approximately RMB1,809.36 million, representing approximately 7.5% of the Group’s revenue.

  • Sales of Gaisanchun capsules amounted to approximately RMB1,047.15
    million, rising by approximately 4.6% as compared with the last year.
  • Sales of Yigu injections amounted to
    approximately RMB315.05 million, a remarkable increase of approximately 68.8%
    against the last year.

 

Digestive system medicines

–    The sales of digestive system medicines amounted
to approximately RMB1,529.55 million, representing approximately 6.3% of the Group’s revenue.

  • Sales of Aisuping
    injection
    amounted
    to approximately RMB949.25 million, a significant increase of
    approximately 26.5% as compared with the last year.
  • Sales of Getai tablets amounted to approximately
    RMB327.29 million, an increase of approximately 37.6% as compared with the last
    year.
  • Sales of Deyou granule
    amounted to approximately RMB176.84 million, a remarkable increase of
    approximately 66.8% as compared with the last year.
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Respiratory system
medicines

–    The sales of respiratory medicines amounted
to approximately RMB1,084.61 million, representing approximately 4.5% of the Group’s revenue.

  • Sales of Tianqingsule
    inhalation powder amounted to approximately RMB627.43 million, an
    increase of approximately 24.3% as compared with the last year.

 

Anti-infectious medicines

–    The sales of anti-infectious medicines amounted
to approximately RMB1,032.19 million, representing approximately 4.3% of the Group’s revenue.

  • Sales of Tiance injections amounted to approximately
    RMB564.49 million.
  • Sales of Tianjie
    injections amounted to approximately RMB308.10 million, an increase of
    approximately 37.5% against the last year.
  • Sales of Tianli
    (Linezolid and Glucose) injections amounted to approximately RMB98.78 million,
    a significant increase of approximately 101.1% against the last year.

 

Others

–    The sales of others amounted to approximately RMB4,494.43 million, representing approximately 18.4% of the Group’s revenue.

  • Sales of Debaian
    Cataplasm
    amounted
    to approximately RMB1,066.98 million, increased by approximately 42.4% against
    the last year.

 

R&D

During the year, the total R&D
expenditure (including expensed off in the statement of profit or loss and
recorded as development costs in the statement of financial position) amounted
to approximately RMB2,651.53 million, which accounted for approximately 10.9%
of the Group’s revenue.

 

The Group has continued to focus
its R&D efforts on new hepatitis, oncology, respiratory system and
cardio-cerebral medicines. During the fourth quarter, the Group was granted 9
clinical trial approvals, 9 production approvals, and 6 approvals for
Consistency Evaluation, and made 6 clinical trial applications, 4 applications
for Consistency Evaluation and 11 production applications. Cumulatively, a
total of 486 pharmaceutical products had obtained clinical trial approval, or
were under clinical trial or applying for production approval. Out of these, 34
were for hepatitis medicines, 204 for oncology medicines, 27 for respiratory
system medicines, 27 for endocrine, 50 for cardio-cerebral medicines and 144
for other medicines.

 

The Group also emphasizes on
the protection of intellectual property rights. It encourages its subsidiaries to
apply for patent applications as a means to enhance the Group’s core
competitiveness. During the fourth quarter, the Group has received 23
authorized patent notices (all were invention patents) and filed 83 new patent
applications (77 invention patents, 1 utility model patents and 5 apparel
design patents). Cumulatively, the Group has obtained 766 invention patent
approvals, 23 utility model patents and 90 apparel design patents.

 

Prospects

Looking ahead to 2020, the
implementation of measures including the launch of and adjustments to the New
National Medical Reimbursement Drug List, realization of payment categorized
under DRG, the Key Monitoring Drug List and performance evaluation of hospitals
will speed up the adjustments to the products and overall industry landscapes,
hence the turning point of the survival of the fittest gradually emerged in the
industry. The implementation of new measures encouraging innovation will
accelerate the approval and launch of innovative products. Leading local
enterprises in the country will be confronted with more intense competition
from multinational companies in terms of innovative products. Those companies
like Sino Biopharm, which have strong innovative and R&D capabilities and
continuously launch new products in the market, highlight their advantages. In
addition to marketing more new products and consolidating its dominant position
in the hepatitis and oncology small molecular drug sectors, the Group also
places high value on the increasingly important treatment and market value of
biopharmaceutical medicines and thus has adopted a comprehensive roadmap
covering different facets from R&D to the production.

 

Also, in order to cope with the
spread of the novel coronavirus around the world, the Group has maintained
ample liquidity. As of 31 December 2019, its cash and bank balances amounted to
approximately RMB11.91 billion, which is sufficient for withstanding any shocks
that may result from abrupt changes in the economic and industry environments.
Facing the fierce outbreak, the Group promptly made the decision in late
January 2020 to issue zero coupon convertible bonds with a principal amount of
EURO750 million. This move consequently generated more abundant funds for the
Group. The Group will make good use of its capital and competitive advantages, to
actively seek for high-quality acquisitions, investments and cooperation
projects, to expand its core pharmaceutical business, as well as to comprehensively
promote its greater healthcare development strategy, so as to lay the
foundation for the Group’s rapid development in the next decade.

 

Stepping into 2020, 5G network
and devices have become more popular in Mainland China. As such, the Group will
continue to step up its investment in big data, digitalization and artificial
intelligence, as well as increase the use of related advanced technologies.
These strategies will allow Group not only to further enhance its efficiency in
management, R&D, production and sales, but also create greater value for
the industry and patients and promote the development of “patient-oriented”
pharmaceutical services, pharmaceutical care services and chronic disease
management systems, providing full course disease management solutions from
which patients can benefit.

 

Some newly approved products

New indication of
Anlotinib Capsules( FOCUS V®)

Anlotinib has obtained the approval for a new
indication for soft tissue sarcoma, becoming the first such targeted drug
approved in China. It has also been included in the guidelines for the
diagnosis and treatment of soft tissue sarcoma by the Chinese Society of
Clinical Oncology.

Gadoxetic Acid Disodium Injection (Xian’ai)

This
liver-specific magnetic resonance contrast agent is the first generic drug of
its type in China. The product is able to increase the detection rate of
small liver tumors, facilitating early diagnosis and treatment of liver
lesions. It is also expected to replace invasive examinations and has piqued
the widespread interest of the industry.

 

Iodixanol Injection

Iodixanol
is the only X-ray diagnostic contrast agent that is isotonic with blood. It
is recognized and recommended by numerous domestic and international clinical
guidelines and expert consensus for enhancing the lesion detection rate and
functioning as diagnostic identification in the examinations of organ disease
in the nervous and cardiovascular systems, chest, abdomen, pelvis, etc. As
the third generic drug of its type in China, this product is expected to
complement Xian’ai in the area of marketing.

 

Rivaroxaban Tablet

Rivaroxaban
is an important product for preventing vein thrombosis after orthopedic
operations. The Group has succeeded in producing and launching the first
generic drug for this medicine.

Apixaban Tablet

Apixaban
is applicable to adult patients who have undergone hip joint or knee joint
elective replacement to prevent venous thromboembolism. Apixaban has a wider
therapeutic window and broader market prospects. Apixaban tablets has been
included in the New National Medical Reimbursement Drug List and is expected
to become the major new product in the portfolio of the Group.

Abiraterone Acetate Tablet (Qingkeshu)

Abiraterone
Acetate Tablet is a drug for prostate cancer treatment of new mechanism of
action. It has been designated as a first-line or second-line treatment
option for prostate cancer by European and American clinical guidelines. Prostate
cancer is the second most common type of tumor in men worldwide. In China,
prostate cancer is the most common genitourinary
cancer in men.

Fosaprepitant Dimeglumine for Injection

This
neurokinin-1 (NK-1) antiemetic drug is recommended in numerous domestic and overseas
guidelines. The Group is one of the first batch of domestic enterprises
successfully producing a generic drug of this kind. This product can
perfectly complement the Group’s oncology medicine product line, which has
already enjoyed the advantage, and is expected to become a heavyweight
product in its oncology product line.

Caspofungin Acetate for Injection

This first
new echinocandin antifungal drug has broad-spectrum antifungal activity. It
has become the market’s star product among the antifungal drugs for systemic
use.

Tofacitinib Citrate Tablet (Tai’yan)

This oral
small molecule inhibitor of JAK1/JAK3. Tofacitinib has promising efficacy for
treating rheumatoid arthritis, ulcerative colitis, active psoriatic
arthritis, moderate-to-severe active ulcerative colitis. The Group is the
first in the country to produce generic drugs of this kind. The Group has
also obtained approval for Celecoxib Capsule, a classic osteoarthritis
medicine with wide indications and a mature market. With the approval of
Taiyan, the value of the osteoarthritis drug product lines has also surged
substantially.

About Sino Biopharmaceutical Limited (HKEX:1177)

Sino Biopharm
Limited is a leading, innovative research and development driven pharmaceutical
conglomerate in the PRC. Its business encompasses a fully-integrated chain
which spans from R&D to the manufacture and sales of pharmaceutical
products. The Group’s products have gained a competitive foothold across
various therapeutic categories with promising potential, covering a vast array
of biopharmaceutical and chemical medicines for treating tumors, liver
diseases, respiratory system diseases, cardio-cerebral diseases and orthopedic
diseases.

 

Sino Biopharm is a constituent stock of the
following indices: MSCI Global Standard Indices — MSCI China Index, Hang Seng
Index, Hang Seng Index — Commerce & Industry, Hang Seng Composite Index,
Hang Seng Composite Industry Index — Consumer Goods, Hang Seng Composite
LargeCap Index, Hang Seng Composite LargeCap & MidCap Index, Hang Seng
China (Hong Kong-listed) 100 Index and Hang Seng Stock Connect Hong Kong Index.
Sino Biopharm was ranked as one of “Asia’s Fab 50 Companies” by Forbes Asia for
three consecutive years in 2016, 2017 and 2018.

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